Autophagy and Disease

In adult cancers, seemingly normal cells respond inappropriately to stress by proliferating and becoming refractory to apoptosis. These cells can be thought of as in a continual state of repair, attempting to heal a wound which they-themselves are creating. Autophagy...

Sensory Neuropathy

Glaucoma is a subset of neurodegenerative diseases and is extremely common in the US, but the molecular correlates leading to the optic nerve dysfunction is unclear. Auditory systems in animals consist of a cache of modules which can each be damaged in explosive...

Introduction

Idiopathic diseases (particularly neuro-degenerative and oncologic) continue to make diagnosis and treatment difficult due to their undefined nature. Many of these diseases have a heritable component, and for some, it is the primary underlying etiology. With Whole...