In adult cancers, seemingly normal cells respond inappropriately to stress by proliferating and becoming refractory to apoptosis. These cells can be thought of as in a continual state of repair, attempting to heal a wound which they-themselves are creating. Autophagy is one of the cellular processes which is active when cells are in this state-of repair. Investigating the connections of autophagy after stresses chemotherapy and chronic inflammation will be important to determine how the cells are adapting to these stresses and at which point in the chain of interacting cells is the benefit acquired.
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